The C.A.R. appears to have been settled from at least the 7th century on by overlapping empires, including the Kanem-Bornou, Ouaddai, Baguirmi, and Dafour groups based in Lake Chad and the Upper Nile. Later, various sultanates claimed present-day C.A.R, using the entire Oubangui region as a slave reservoir, from which slaves were traded north across the Sahara and to West Africa for export by the Europeans. Population migration in the 18th and 19th centuries brought new migrants into the area, including the Zande, Banda, and Baya-Mandjia.

In 1875 the Egyptian sultan Rabah governed Upper-Oubangui, which included present-day C.A.R. Europeans, primarily the French, German, and Belgians, arrived in the area in 1885. The French consolidated their legal claim to the area through an 1887 convention with Congo Free State, which granted France possession of the right bank of the Oubangui River. Two years later, the French established an outpost at Bangui, and in 1894, Oubangui-Chari became a French territory. However, the French did not consolidate their control over the area until 1903 after having defeated the forces of the Egyptian sultan, Rabah, and established colonial administration throughout the territory. In 1906, the Oubangui-Chari territory was united with the Chad colony; in 1910, it became one of the four territories of the Federation of French Equatorial Africa (A.E.F.), along with Chad, Congo (Brazzaville), and Gabon. The next 30 years were marked by smallscale revolts against French rule and the development of a plantation-style economy.

In August 1940, the territory responded, with the rest of the A.E.F., to the call from Gen. Charles de Gaulle to fight for Free France. After World War II, the French Constitution of 1946 inaugurated the first of a series of reforms that led eventually to complete independence for all French territories in western and equatorial Africa. In 1946, all A.E.F. inhabitants were granted French citizenship and allowed to establish local assemblies. The assembly in C.A.R. was led by Barthelemy Boganda, a Catholic priest who also was known for his forthright statements in the French Assembly on the need for African emancipation. In 1956 French legislation eliminated certain voting inequalities and provided for the creation of some organs of self-government in each territory. The French constitutional referendum of September 1958 dissolved the A.E.F., and on December 1 of the same year the Assembly declared the birth of the Central African Republic with Boganda as head of government. Boganda ruled until his death in a March 1959 plane crash. His cousin, David Dacko, replaced him, governing the country until 1965 and overseeing the country's declaration of independence on August 13, 1960.

On January 1, 1966, following a swift and almost bloodless coup, Col. Jean-Bedel Bokassa assumed power as president of the Republic. Bokassa abolished the constitution of 1959, dissolved the National Assembly, and issued a decree that placed all legislative and executive powers in the hands of the president. On December 4, 1976, the republic became a monarchy with the promulgation of the imperial constitution and the proclamation of the president as Emperor Bokassa I. His regime was characterized by numerous human rights atrocities.

Following riots in Bangui and the murder of between 50 and 200 schoolchildren, former President Dacko led a successful French-backed coup against Bokassa on September 20, 1979. Dacko's efforts to promote economic and political reforms proved ineffectual, and on September 20, 1981, he in turn was overthrown in a bloodless coup by Gen. Andre Kolingba. For 4 years, Kolingba led the country as head of the Military Committee for National Recovery (CRMN). In 1985 the CRMN was dissolved, and Kolingba named a new cabinet with increased civilian participation, signaling the start of a return to civilian rule. The process of democratization quickened in 1986 with the creation of a new political party, the Rassemblement Democratique Centrafricain (RDC), and the drafting of a new constitution that subsequently was ratified in a national referendum. General Kolingba was sworn in as constitutional President on November 29, 1986. The constitution established a National Assembly made up of 52 elected deputies, elected in July 1987. Due to mounting political pressure, in 1991 President Kolingba announced the creation of National Commission to rewrite the constitution to provide for a multi-party system. Multi-party presidential elections were conducted in 1992 but were later cancelled due to serious logistical and other irregularities. Ange Felix Patasse won a second-round victory in rescheduled elections held in October 1993, and was re-elected for another 6-year term in September 1999.

Salary arrears, labor unrest, and unequal treatment of military officers from different ethnic groups led to three mutinies against the Patasse government in 1996 and 1997. The French succeeded in quelling the disturbances, and an African peacekeeping force (MISAB) occupied Bangui until 1998 when they were relieved by a UN peacekeeping mission (MINURCA). Economic difficulties caused by the looting and destruction during the 1996 and 1997 mutinies, energy crises, and government mismanagement continued to trouble Patasse's government through 2000. In March 2000 the last of the MINURCA forces departed Bangui. In May 2001 rebel forces within the CAR military, led by former President and army General Andre Kolingba, attempted a military coup. After several days of heavy fighting, forces loyal to the government, aided by a small number of troops from Libya and the Congolese rebel Movement for the Liberation of the Congo (MLC), were able to put down the coup attempt. In November 2001, there were several days of sporadic gunfire between members of the Presidential Security Unit and soldiers defending sacked Chief of Staff of the Armed Forces Francois Bozize, who fled to Chad. In mid-2002 there were skirmishes on the CAR-Chad border.